Pronouns: E/em/eir/eirs/eirself.
An ordinary frilled lizard uplifted to anthropomorphism and sentience who went on to earn a doctorate in clinical psychology. Eir practice (offering both spa services and talk therapy) is based in the same town as Dr. Mutable's laboratory, and employs Prima as a receptionist. Don't be fooled by eir gentle, pleasant, mild-mannered demeanor; this is also a kinky and dubiously ethical mad scientist situation. However, e does take the therapy goals of eir brainwashed patients seriously. When eir frill extends, the gently glowing spiral patterns stun and entrance onlookers.
Gentle but firm in the dominant role and subtly boundary-pushing in the submissive role.
* Artfight
Pronouns: She or Ze/zir/zirs/zirself
A sinister, solitary scientist whose experimentation on zirself produced an unconventional werewolf. For most of the month, the mark of zir lycanthropy is the sharp-toothed mouth at the end of zir tail, which has a rudimentary independent personality of its own mostly centered around biting whatever gets too close (hence the muzzle). During the full moon, the tail grows into a monstrous wolf and Dr. Hyland is reduced to the tip of its tail, carried along by its whims (still pretty bite-focused). Ze lives on the outskirts of the town where Dr. Mutable's lab is based, and is Dr. Mutable's friendly rival / sloppy makeout partner / mutual test subject. Ze has a sardonic, bitter, above-it-all affect but gets intense about subjects ze's excited about.
Prefers a dominant role.
* Artfight
Pronouns: She/they/any
A cheerfully amoral but generally harmless mad scientist who "terrorizes" a small Minnesotan town (perpetrates kinky chaos that the residents are largely indifferent to, you know how wish fulfilment settings are.) A former human who genespliced herself into her current form in the spirit of reckless experimentation and spitting in the eye of God. Although she's well versed in big clanky machines, toon physics gadgets, and transformation ray guns, she specializes in potions and serums, including developing and distributing bespoke fantasy-HRT regimens.
Dominant-leaning switch, equally happy to transform herself or be transformed.
Q: "is there any backstory to how doctors hyland and mutable met?"
Dr. Mutable has been making her hometown steadily weirder since failing out of university and Dr. Hyland originally moved there to fulfil simultaneous goals of: being in collaboration-range with a like-minded mad scientist, being in a place where she doesn't particularly stand out day to day¹, and needing to get away from the wreckage of a werewolf rampage quick-like. There was some polite if arch/supervillainesque mail correspondance about their research at first, and then one of them inevitably ambushed the other with an experimental transformation ray and it transitioned smoothly to a sort of Narbonic x Spy Vs Spy scenario.
¹: it's a mixed human/anthro universe anyway and Dr. Mutable is not the only one breaking the laws of biology over her knee so Hyland is not, like, a "fleeing from cryptid hunters and government researchers" kind of anomaly. But she is visibly Weird.
Q: "what are mutable & hyland's respective labs like, if you've thought about it? i assume "vague cartoon mad science lab" but like, underground lair? spooky castle? floating fortress?"
Mutable has a shiny modern laboratory whose surface level is sort of passably normal but it sits on top of an apparently endless labyrinth of basements and sub-basements which can be quite strange as you get deeper. Bubbling vats and ominous lights and entire rooms packed with strange machinery of no obvious purpose, and so on. Meanwhile Dr. Hyland does all her science in an ominous rundown mansion out in the woods. Terrible lighting, creaky floors. Every shelf, bench, and cabinet is a complete jumble of tools and parts and random junk with no discernable order to it all but she'll yell at you if you try to move anything.
* Artfight
Pronouns: She/her.
Random's older sister, who remains an archaeopteryx to serve as the Doylist control group for Random's transformations. She's supportive if occasionally sarcastic and teasing about her sibling's kinky occupation. It's not like she's in a position to throw stones, as the receptionist for Dr. Frillneck's hypnotic spa & therapy office.
She doesn't think of herself in terms of a BDSM role, but she's got a bit of the archetype "a confident person who's certain that hypnosis obviously isn't going to work on her right up until the pendulum actually starts to swing."
Pronouns: They/it, or any pronouns you think are appropriate to their current form.
A grad student studying pharmacology, Random's official position is an intern assisting Dr. Mutable, but in practice seems to be more of a test subject for various transformations. They are identifiable by color scheme and strong visual motifs, while their species is constantly changing. The high concept here is a transformation-bait character who doesn't return to a persistent/original form between transformations; everything they've become has been a fluid, continuous sequence. They're nervous and easily flustered, but most certainly enjoying their job.
Submissive and transformable.
* Artfight